9/15/2023 0 Comments Checkpoint ssl extender![]() ![]() ![]() Moreover, its assessment in on-treatment samples was able to better predict clinical efficacy, regardless of the TFx levels at baseline. TFx at baseline correlated with metastatic lesions at the bone and the liver, and high TFx (≥10%) associated with ICIs benefit. From sWGS data, we computed the tumor fraction (TFx) and somatic copy number alterations (SCNAs) burden and associated them with ICIs benefit and clinical features. Over 150 samples were obtained before ICIs treatment initiation and at several time points throughout treatment. We applied sWGS on cell-free DNA (cfDNA) extracted from plasma samples of 45 patients with metastatic NSCLC treated with ICIs. ![]() Here, we assessed the value of shallow whole-genome sequencing (sWGS) on plasma samples to monitor ICIs benefit. Nevertheless, only a portion of patients benefit from this type of treatment. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis are the main therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) without a druggable oncogenic alteration. ![]()
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